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eMediNexus 26 November 2021
Gustafsson et al sought to determine the significance of gastro-esophageal reflux (GER) as a trigger of asthma. Therefore, they conducted a double-blind, cross-over, placebo-controlled trial over four weeks to evaluate the impact of inhibition of gastric acid secretion on asthma. Overall, 37 children and adolescents, mean age 14 years, with bronchial asthma were studied.
Ranitidine 300 mg was given as a single evening dose over the study duration. A dose of 150 mg was given in those with body weight less than 40 kg.
Eighteen of the 37 patients were found to have pathological GER through 24 h pH monitoring in the esophagus in prior investigations. Rest of the 19 patients with normal GER acted as controls for the effects of ranitidine on asthma, not related to decrease in GER.
Source: Gustafsson PM, Kjellman NI, Tibbling L. A trial of ranitidine in asthmatic children and adolescents with or without pathological gastro-oesophageal reflux. Eur Respir J 1992;5:201-6.
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